Iranian Journal of Ceramic Science & Engineering
Volume 8, Issue 1 (5-2019)
2019, 8(1): 13-25 |
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Synthesis of nano HA/βTCP mesoporous particles using a simple modification in granulation method in PVA/ Oil and investigation of biological response. Iranian Journal of Ceramic Science & Engineering 2019; 8 (1) :13-25
URL: http://ijcse.ir/article-1-670-en.html
URL: http://ijcse.ir/article-1-670-en.html
Abstract: (2725 Views)
Granulation method in the mixture of oil, water, and PVA was used to synthesize HA/βTCP porous nano-powders. Results showed that the presence of oil in PVA/oil system results in crystallization of mesoporous HA/βTCP particles with the surface area of 93 cm2/g. Using Rietveld method, the amounts of HA/βTCP and amorphous phases in the oven-dried PVA substrate powders after heat-treatment were calculated as about 65, 13, and 22 wt.%, respectively. RSM modeling showed that TEOS is the optimum surfactant in this method. Bioactivity test showed that HA/ βTCP sample is bioactive in SBF medium. According to cell viability results, synthesized powder in the presence of oil/PVA, which was then modified by 25 wt.% of TEOS, did not cause toxicity. Using Alizarin Red S staining quantification assay, it was found that after modification by TEOS, bone-nodule formation was enhanced by 25%.
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